Construction of spirocyclic oxindoles is one of the most frequently cited articles
The generation of all-carbon quaternary stereocenters and the construction of highly strained polycyclic structures is one of the greatest challenges for organic chemists. Both are structural features of many natural products and medicinal compounds.
The spirocyclic oxindole core is an example of these challenging structures.
In this paper, Paolo Melchiorre
and his team develop a direct one-step synthesis of spirocyclic oxindoles by asymmetric organocascade catalysis. They use two different organocatalysts that activate carbonyl compounds, such as ketones and aldehydes, with extraordinary levels of stereocontrol.
If you want to find out about those catalysts read the article here
and to see the list of articles that, together with this one, have contributed the most to Angewandte's 2011 impact factor go here
Giorgio Bencivenni, Li-Yuan Wu, Andrea Mazzanti, Berardino Giannichi, Fabio Pesciaioli, Mao-Ping Song, Giuseppe Bartoli, Paolo Melchiorre
Angew. Chem. Int. Ed. 2009, vol. 48, pp. 7200–7203