Inspired by mimicking the characteristics of terpenoid cyclase enzymes, the goal of this proposal is to design new types of catalysts containing electrophilic transition metal centers that could simultaneously fold and activate polyunsaturated substrates promoting non-inherent cyclization modes. Our goal is unprecedented, although it is rooted on fundamental organometallic chemistry, in particular, on the known […]
Bioinspired Catalytic Metallofoldamers
A new platform technology for the on-demand access to large acenes
The aim of PLAT_ACE is to study the technical and commercial viability of this novel synthetic methodology and its industrial implementation for the generation of nonacene and other larger acenes supported onto surfaces for use in semi-conducting devices with unprecendeted electronic properties and low bandgap. Our technology will be benchmarked against current industrial methodologies to […]
Química Organometàl.lica en Síntesi Orgànica
Dinuclear Gold Catalysis: A New Platform for Cross-Coupling Reactions
Gold catalysis has become a powerful tool for organic chemists to streamline synthesis of valuable and complex molecules. Compared to other transition metals, gold complexes are remarkably stable towards air and water, and are essentially nontoxic, which make them ideal candidates to execute catalytic cross-coupling reactions in industry or in vivo. TWINGOLD aims at broadening […]
Polynuclear Gold Cluster Catalysis
Gold catalysis has become an extremely attractive research field these last decades as it has been considered one of the most effective methodologies for constructing carbon-carbon or carbon-heteroatom bonds. However, the development of enantioselective catalysis mediated by gold is relatively slow, mainly due to (i) the preferred linear two-coordinated mode of AuI complexes in the […]
Juan de la Cierva-Incorporación – Miguel Peña
FPI Fellowship – Cristina García
ICIQ International PhD Fellowship Programme on Catalysis for Life and Biosciences-Eric Tan
FPU fellowship – Sofia Ferrer
ICIQ-International PhD Programme “La Caixa” Severo Ochoa-Margherita Zanini
Contrato predoctoral Severo Ochoa-Elena de Orbe
Polynuclear Gold Catalysis
During the last decade, homogeneous gold catalysis has witnessed rapid growth for C–C bond forming reactions mainly due to the soft carbophilic Lewis acid properties of gold complexes toward C–C triple bonds. Compared to Lewis acids and other transition metals, gold catalysts are very active under mild conditions, can tolerate moisture and oxygen and are […]
Catalizadores electrofílicos avanzados para la síntesis de sistemas complejos
This proposal aims at developing enabling methodologies based on the homogeneous catalysis of gold and other transition metals to streamline the organic synthesis of complex molecules. One of our goals is the synthesis of new chiral metal catalysts, bimetallic complexes and well-defined electrophilic polynuclear clusters for the development of new catalytic applications. An important objective […]
From gold to silver: streamlining metal-catalysed cross-coupling reactions
Silvercatpharma project aims at developing C-C cross-coupling reactions catalysed by d11-blocks metals, particularly silver, for the synthesis of pharmaceuticals in Novartis. It strives to have an impact in terms of cost, environment and international visibility because of the use of silver as an alternative catalyst. The project offers me a great opportunity to obtain further […]