Our society depends on thousands of indispensable molecules such as pharmaceuticals, agrochemicals, dyes, and coatings. Such products are synthesized from starting materials that originate from fossil resources, mainly oil. As oil is depleting, alternative starting materials are needed. CO2 is a benign and sustainable carbon source, which in analogy to natural photosynthetic processes can be […]
Cooperation towards a sustainable chemical industry
Nickel-catalyzed bond-forming reactions with native functional groups
Over the last century, cross-coupling reactions have had a transformative impact in synthetic organic chemistry. Indeed, the high chemoselectivity achieved when coupling nucleophilic fragments (boronic acids, organozincs, Grignard reagents, etc) with electrophilic counterparts (typically aryl or alkyl halides) has contributed to the full adoption of these methods in both industrial and academic laboratories. Practicality and […]
De Novo Fatty Acid Synthesis from Alkane Feedstocks and CO2
FAT-FEEDOX deals with the development of an innovative and unconventional catalytic de novo approach to fatty acids, privileged motifs on the manufacture of detergents, soaps, dyes, plastics, agrochemicals and pharmaceuticals, using simple, available and abundant carbon dioxide (CO2) and alkanes, compounds derived from the crude oil. Specifically, FATFEEDOX will promote a synergistic catalytic C(sp3)–H activation […]
Late-stage catalytic carboxylation techniques wiht labelled carbon dioxide: new opportunities for radiolabelling
Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with […]
Functionalization of ethereal C-O Bonds Enabled by Metallophotoredox Catalysis
The direct utilization of native functional groups without the need for prefunctionalized holds considerable promise to revolutionize organic synthesis. While significant advances have been realized within the area of C-H activation, the functionalization of inert C-O bonds in aryl ethers is still at its infancy. Prompted by the natural abundance of aryl ethers in Lignin, […]
The combination of Electrochemistry and Nickel Catalysis: New Bond-Forming Reactions on a Sustainable Platform
Sustainable routes towards the formation of key synthetic carbon–carbon bonds by cross-coupling remains a challenge in organic chemistry. Realization of this goal will enable the combination of simple building blocks to rapidly assimilate synthetic complexity with only a minimum level of stoichiometric waste. Electrochemistry provides a new platform to conduct reactions through in situ generation […]
Grup d’Activació Catalítica d’Enllaços Inerts
Nickel-catalyzed functionalization of carbon oxygen bonds for building up molecular complexity
La Caixa Severo Ochoa-Raúl Martín
FPI Fellowship – Alberto Tampieri
FPI Fellowship – ShangZheng Sun
Carboxilación de materia orgánica con dióxido de carbono catalizada por metales de transición
The novo catalytic synthesis of β-aminoacids from CO2
This proposal deals with the development of an innovative and unconventional catalytic de novo approach to β-amino acids, compounds of remarkable biological significance, using simple, available and abundant carbon dioxide (CO2) as C1 synthon. Specifically, NOVOCAT will promote a synergistic catalytic C-N bond-cleavage/CO2 insertion event of readily available aziridines from a synergistic and rather challenging […]