In this work, the authors have developed an efficient Ni-catalyzed protocol for the reductive cleavage of inert C−O bonds. The method is characterized by its simplicity and wide scope, thereby allowing the use of aryl ethers as easily removable directing groups in organic synthesis.
The article Nickel-Catalyzed Reduction of Inert C-O Bonds: A New Strategy for Using Aryl Ethers as Easily Removable Directing Groups , authored by Drs. Rubén Martín and Paula álvarez-Bercedo and published in J. Am. Chem. Soc. 2010, 132, 17352-17353, has been selected by the Editorial Board of SYNFACTS for its important insights. This article has been also highlighted in Synform.