Gold(I)-catalyzed activation of alkynes followed by nucleophilic attack have been extensively studied in our group. In this work, the developpement of a new reaction catalyzed by Au (I) using trimethylsilyl azide and alkynes leading to the formation of tetrazoles is first established. Then, the intermolecular trapping of the in situ formed Au (I)-carbenes with different novel nucleophiles is described. Finally, the 1,5-migration reaction of 1,6-enynes catalyzed by Au (I) is applied to the synthesis of the natural products (+)-schisanwilsonene A, B and C which possess interesting biological activity against hepatitis B.
Gold(I) – Catalyzed Cyclizations and Enantioselective Total Synthesis of (+) – Schisanwilsonene A
Oct 14, 2014 | 11:30
Lecturer: Morgane Gaydou
Supervisor: Professor Antonio M. Echavarren
2014-10-14 11:30:00 2014-10-14 12:30:00 Europe/Paris Gold(I) – Catalyzed Cyclizations and Enantioselective Total Synthesis of (+) – Schisanwilsonene A Lecturer: Morgane Gaydou
Lecturer: Morgane Gaydou
Supervisor: Professor Antonio M. Echavarren
2014-10-14 11:30:00 2014-10-14 12:30:00 Europe/Paris Gold(I) – Catalyzed Cyclizations and Enantioselective Total Synthesis of (+) – Schisanwilsonene A Lecturer: Morgane Gaydou