The paper describes the visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor–acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.
Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters
Ł. Woźniak, J. J. Murphy, P. Melchiorre
J. Am. Chem. Soc., 2015, 137, 5678-5681