The adduct [MeO → Bpin–Bpin]− efficiently mediates the β-boration of α,β-unsaturated imines formed in situ. The use of chiral phosphines as additives, and in particular the chiral phosphine (S)-MeBoPhoz, enables the catalytic asymmetric reaction to proceed with higher enantioselectivity than the analogue copper(I) mediated reaction.
Asymmetric metal free β-boration of α,β-unsaturated imines assisted by (S)-MeBoPhoz
GO TO OPEN ACCESS Org. Biomol. Chem. 2015, 13, 1328-1332.