An integrated catalytic decarboxylation/carboxylation for accessing isotopically labeled carboxylic acids with 13CO2 or 14CO2 is described. The method shows a wide scope under mild conditions, even in the context of late-stage functionalization, and does not require stoichiometric organometallics, thus complementing existing carbon-labeling techniques en route to carboxylic acids.
Catalytic Decarboxylation/Carboxylation Platform for Accessing Isotopically Labeled Carboxylic Acids
GO TO OPEN ACCESS ACS Catal. 2019, 9 (7), 5897-5901, DOI: 10.1021/acscatal.9b01921.
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