Molecular recognition: Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate-protein recognition. The interaction of a three-component DCL based on 2,2′-bipyridine (bipy)-FeII complexes with concanavalin?A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose-containing library components.
Dynamic Multivalency for Carbohydrate-Protein Recognition through Dynamic Combinatorial Libraries Based on FeII-Bipyridine Complexes
Chem. Eur. J. 2013, 19, 5259-5262.