The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold-catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethylsilyl).
![Enantioselective synthesis of (-)-Englerins A and B](https://www.iciq.org/wp-content/uploads/2014/03/Enantioselective-synthesis_3517.gif)