The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold-catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethylsilyl).
Enantioselective synthesis of (-)-Englerins A and B
Angew. Chem. Int. Ed. 2010, 49, 3517-3519.