A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.
![Formal ?-alkynylation of ketones via Pd-catalyzed C-C cleavage](https://www.iciq.org/wp-content/uploads/2014/03/Formal-alkynylation_chemcomm20R.20Martin.gif)
A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.