Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(μ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.
![Highly active [Pd(?-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides](https://www.iciq.org/wp-content/uploads/2014/03/Highly-active-Pd-ClClNH_2915.gif)