A site-selective catalytic incorporation of multiple CO2 molecules into 1,3-dienes en route to adipic acids is described. This protocol is characterized by its mild conditions, excellent chemo- and regioselectivity and ease of execution under CO2 (1 atm), including the use of bulk butadiene and/or isoprene feedstocks.
Ni-Catalyzed Site-Selective Dicarboxylation of 1,3-Dienes with CO2
J. Am. Chem. Soc. 2018, 140 (6), 2050-2053 , DOI: 10.1021/jacs.7b13220.
* Highlighted in Chemistry Views.
** Among the most read articles in February 2018.