The photoredox activation of inert chloroalkanes for the cross-coupling reaction with olefins, with a broad functional group tolerance under mild conditions is presented. By combining UV/Vis spectroscopy, EPR, radical clock and deuterium-labelling experiments, [Ni(Py2Tstacn)]+ is proposed to be catalytically competent to activate the Csp3−Cl bond, forming a free radical, which reacts with the alkene.
Photoredox Activation of Inert Alkyl Chlorides for the Reductive Cross-Coupling with Aromatic Alkenes
Angew. Chem. Int. Ed. 2022, e202114365, DOI: 10.1002/anie.202114365.