Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum–phenanthroline complex
Chem. Commun. 2007, 4366-4368.