This lecture intends to showcase unorthodox ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations, including trans-hydrogenation, trans-hydroboration, trans- hydrostannation, and trans-hydro(chloro)alkynylation, which have little precedent in the literature, if any.
Even more perplexing is the ability to transfer both H-atoms of H2 to one and the same C-atom of a triple bond with concomitant formation of a discrete metal carbene at the adjacent position (“gem- hydrogenation”). This entirely new reactivity mode unlocks numerous opportunities for organic synthesis and organometallic chemistry alike, which we have started to explore.
The underlying mechanisms will be discussed in some detail; selected applications to target-oriented synthesis are meant to showcase the current state of development.
A. Fürstner, J. Am. Chem. Soc. 2019, 141, 11.
If you are interested in attending in the Auditorium, please, fill in this registration form to be sure that we do not exceed the maximum capacity. (It will be assigned on a first-come/first served basis). We will confirm your acceptance through an e-mail 24h before the event.