Abstract
This lecture intends to showcase unorthodox ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations, including trans-hydrogenation, trans-hydroboration, trans- hydrostannation, and trans-hydro(chloro)alkynylation, which have little precedent in the literature, if any.
Even more perplexing is the ability to transfer both H-atoms of H2 to one and the same C-atom of a triple bond with concomitant formation of a discrete metal carbene at the adjacent position (“gem- hydrogenation”). This entirely new reactivity mode unlocks numerous opportunities for organic synthesis and organometallic chemistry alike, which we have started to explore.
The underlying mechanisms will be discussed in some detail; selected applications to target-oriented synthesis are meant to showcase the current state of development.
A. Fürstner, J. Am. Chem. Soc. 2019, 141, 11.
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