Late-stage functionalization (LSF) is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or time-consuming to prepare otherwise; hence, this strategy has a great potential to impact drug discovery processes by speeding up the hit-to-lead optimization. At present, more than two-thirds of prescription […]
Juan de la Cierva Fellowship – Bowen Li
FPI Fellowship – Norman Diaz Aguayo
A new catalytic platform for the enantioselective functionalizations of C-C bonds
FI Fellowship – Guillaume Mollaert
MSCA-COFUND I2:ICIQ Impulsion – Karen de La Vega
FPI-SO Fellowship – Alessio Puggioli
FI Fellowship – Valero Gimeno
Late-stage diazomethylations to impact urgent & unmet medical needs
FPI Fellowship – Eric Palomo
Carbyne transfer catalysis for C(sp2)–C(sp2) bond (radio)fluorinations
This proposal aims to develop a new C–F bond-forming strategy that exploits C–C double bonds as functional groups by means of carbyne transfer catalysis. We want to develop a general and functional group tolerant process that can use petrochemical feedstocks, fine chemicals as well as complex molecules containing alkene functionalities. The new reaction introduce asymmetry […]
Late-stage C–H bond construction of cyclopropanes to impact drug discovery
The cyclopropane ring is the 10th most commonly observed core in small-molecule drugs. This is due to the fact that cyclopropanes can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads. The cyclopropane ring is often introduced in drug candidates at the early stages of the synthesis, however, the late-stage […]
New carbon reactivity rules for molecular editing
The major goal of this application is to develop the catalytic generation of conceptually-novel carbyne equivalents and related species, and to study their reactivity towards organic matter. The catalytic activation of designed sources will reveal new reactivity rules at carbon that have been missing, not only in the design and discovery of new chemical reactions, […]
New carbyne transfer catalysis in organic chemistry
Over the last half century, the challenge of forming metal-carbyne complexes in a catalytic fashion have precluded the discovery of chemical reactions enabling catalytic monovalent carbon transfer process. This proposal aims to circumvent this problem by developing a general platform for the catalytic generation of metal-carbynoid species and to study their reactivity towards organic matter.
ICIQ Starting Career Programme
Síntesis de nuevos derivados antimaláricos a través de una nueva reacción de borilación
FPI Fellowship – Pau Sarró
New Carbon Reactivity Rules
The major goal of this application is to develop the catalytic generation of conceptually-novel carbyne equivalents and related species, and to study their reactivity towards carbon-hydrogen bonds. The catalytic activation of designed sources will reveal new reactivity rules at carbon that chemists have been missing, not only in the design and discovery of new chemical […]