A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.
Xueqiang Wang, Masaki Nakajima, Eloisa Serrano, and Ruben Martin
J. Am. Chem. Soc., 2016, 138 (48), pp 15531–15534 (DOI: 10.1021/jacs.6b10351)