Catalytic chain-walking reactions have recently emerged as a powerful tool for efficiently introducing functionalities at remote sp3 C–H sites within alkyl side chains. Nevertheless, substantial challenges remain when forging multiple C–C bonds while maintaining a predictable site-selectivity profile in chain-walking scenarios, particularly by controlling both regioselectivity and enantioselectivity. This project will explore the ability to […]
FPU Fellowship – Joan Estornell Martinez
FPI Fellowship – Filip Meger
Development of new sp3 C–H carboxylation strategies via interrupted Ni-catalyzed chain-walking catalysis
While originally designed to control the topology of polymers, catalytic chain-walking reactions have recently offered new vistas for forging carbon-carbon bonds at previously unfunctionalized C(sp3)–H sites by formally translocating the metal catalyst throughout the alkyl side-chain of a substrate. In particular, nickel catalysis has positioned at the forefront of this emerging field due to its […]
FPI-SO Fellowship – Julia Ordoñez
Grup d´activació catalítica d´enllaços inerts
FPI Fellowship – Adrian Brenes
Juan de la Cierva Fellowship – Alvaro Velasco
Breaking the barrier – An integrated multidisciplinary approach to kill Gram-negative bacteria through existing antibiotics by making their outer membrane permeable
Antimicrobial resistance, which is caused by multi-drug-resistant bacterial pathogens is a global health emergency. Gram-negative bacteria (GNB) notably hinder effective treatment because of their impermeable outer membrane (OM). Consequently, many standard-of-care (SOC) antibiotics cannot access intracellular targets in GNB. The objective of the BREAKthrough European Training Network (ETN) is to sensitise GNB to these antibiotics […]
De novo sp3 carbon-carbon and carbon-heteroatom bond-forming reactions via catalytic functionalization of native functional groups
Electrophilic aromatic substitution of azines catalysed by Frustrated Lewis pairs
Synthetic chemistry faces numerous reaction barriers to what is actually possible compared to what is theoretically possible. Catalysts are critically important to overcoming many of these barriers by reducing the energy required for a reaction to proceed, often enabling a substitution or functionalisation of simple feedstocks that can lead to high value products. Aromatic substitution, […]
AvH Fellowship – Robert Freund
Escaping from Flatland by “de novo” Catalytic Decarboxylation Techniques
Although cross-coupling reactions have become one of the pillars of modern chemical synthesis, the ability to forge sp3–sp3 bonds with improved flexibility, practicality, predictable site-selectivity, preparative utility, stereocontrol and with nearly zerogeneration of waste has eluded chemists for decades, remaining a major challenge and an uncharted cartography in catalytic endeavours. The successful realization of this […]
FPI Fellowship – Carlota Odena Juan
Metal-catalyzed remote functionalization of aliphatic amines and amides triggered by photocatalytic sp3 C-H activation
Tecnologías Químicas para la Valorización de Residuos Industriales en los Pirineos
This project focuses on the valorization of industrial wastes from agro-alimentary industry (fatty waste) and pesticides (lindane and derivatives) concerning both sides of the Pyrenees. The consortium includes two research laboratories, three industrial piloting and communication organizations, as well as one company. According to the European Commission’s guidelines on innovation, TRIPyr aims to develop state-of-the-art […]
A Remote-carboxylation Strategy for Alcohols via a Dual-catalytic System
The ability to introduce functionality into molecules in a regio- and chemoselective selective manner is of primary importance in the construction of high value molecular compounds but still remains a major challenge for synthetic chemists. The utilization of functionalities present in readily available and inexpensive starting materials to direct the introduction of further complexity is […]