The ICIQ – Medicinal Chemistry Unit is specialized in drug discovery and development processes. It counts with highly qualified personnel working with the ICIQ know-how and state-of-art equipment to offer quickly and optimal solutions for your drug Discovery projects.

Some projects and services available at ICIQ’s MedChem Unit:

• Hit finding: Discovery of new biological active structures for a specific therapeutic target.
• Hit to lead: Chemical structure diversification to improve activity and ADME/TOX properties.
• Lead optimization: Drug design, optimizing target interactions and pharmacokinetic properties through SAR (Structure Activity Relationships).
• Drug development: Synthesis and early-scale-up optimization of selected candidates for clinical trials.
• Custom synthesis: Synthesis of small molecules including impurities, analytical standards, methabolites, chemical markers, catalysts, ligands, etc.
• Route scouting: Design and synthesis of new or alternative synthetic routes for specific target molecules.
• Computational Chemistry Molecular modeling: Computer assisted drug design using state of the art software tailored to the particular characteristics of the binding pocket, improving significantly the efficiency of binding properties of candidates.

ICIQ-MedChem acknowledges the support of the State Research Agency / Ministry of Science and Innovation under the “Severo Ochoa” Centres of Excellence Program (CEX2019-000925-S, MCIN/AEI/10.13039/501100011033, 2020-2024)